It has been reported that some patients have been misdiagnosed with Langerhans Cell Histiocytosis, when in fact the correct diagnosis in their specific case was Osteosarcoma.
Osteosarcoma is a type of cancer that begins in osteoblast cells that form new bone and is a cancer of the youth. Symptoms include swelling near a bone, bone or joint pain, and bone injury or break for no reason. Generally it is found in the long bones of the legs. Osteosarcoma can be misdiagnosed as chondrosarcoma, malignant fibrous histiocytoma, Ewing sarcoma, fibrosarcoma, chordoma, malignant giant cell tumour of bone, and lymphoma that affects bone, chondroblastoma, osteoblastoma, osteomyelitis, Langerhans cell histiocytosis and certain types of bone cysts.